A New York escapee, Shepherd is a first class neurosurgeon looking for a new challenge and a new, less hectic pace of life in Seattle. He’s a firm favourite of chief surgeon Richard Webber, who has him earmarked for chief resident. Skilled, dedicated and a great practitioner of patient focused care, he appears faultless.
But could his attraction to Meredith and his unflinching determination to woo her be his downfall? With fellow senior surgeon Preston Burke hot on his heals, there’s no room for mess ups.

A force to be reckoned with, Cristina has an academically brilliant background and is determined to climb the ladder to success, whatever the cost. She doesn’t care what the other interns think of her she makes sure they know it.

Sandra Oh is aggressive, cut throat and arrogant. Unsurprisingly, she has no bedside manner and no concept of how to relate to her patients. But when a former Grace Hospital nurse ends up being one of her patients we see a glimmer of emotion, suggesting that her tough exterior might have a softer side.

Alex is the smart ass. He’s confident, competitive, arrogant and loves to take the credit. He’s disliked by his fellow interns who dismiss him as shallow and crass. And when it comes to patient care, he couldn’t give a damn.

But his undeniable technical skill and ability to find solutions to complicated problems is plain for all to see. His dream is to become a plastic surgeon and make lots of money – a likely prospect. The question is whether he can drop the ego and focus his talents.