Surgical intern Meredith Grey is passionate, talented and destined for the top. As the daughter of Ellis Grey – one of Seattle’s most respected surgeons – she has great expectation to live up to.

But her focus and dedication is tested when her mother is stricken with Alzheimer’s, a burden that she struggles to keep separate from her work. And when she “accidentally” falls into bed with Sheppard, a senior surgeon, she worries that she’s crossed a dangerous line.

With a tendency towards the melodramatic, Meredith Grey is also a little too forthcoming with advice for patients when it’s unwarranted.

Intern Izzy Stevens will go out of her way to accommodate a patient’s needs, even if it means risking her own career. She works hard and is determined to prove herself and her capabilities. But when a series of photos of her in sexy underwear – taken to fund her through college – are printed in a magazine for all her colleagues and patients to see, she fears she will be judged for all the wrong reasons.

Willowy and beautiful, Izzy Stevens has a debilitating effect on men and is used to having to overcompensate.

But a lack of self-confidence begins to emerge, something she will need to control if she’s going to make it to surgical resident.

The softy in the pack, loveable intern George O’Malley is dependable, has a great bedside manner and makes relating to difficult patients look easy. But his sweet nature and lack of masculine assertiveness also makes him the joker of the pack.

And when T.R. Knight is picked as the first intern to perform in surgery, he chokes in the worst possible way. A lack of confidence and unsteady hands lead to disaster, earning him the nickname: “007 – License to kill.” If he wants to survive his training he must earn respect and prove that he has got what it takes.