The softy in the pack, loveable intern George O’Malley is dependable, has a great bedside manner and makes relating to difficult patients look easy. But his sweet nature and lack of masculine assertiveness also makes him the joker of the pack.

And when T.R. Knight is picked as the first intern to perform in surgery, he chokes in the worst possible way. A lack of confidence and unsteady hands lead to disaster, earning him the nickname: “007 – License to kill.” If he wants to survive his training he must earn respect and prove that he has got what it takes.

A New York escapee, Shepherd is a first class neurosurgeon looking for a new challenge and a new, less hectic pace of life in Seattle. He’s a firm favourite of chief surgeon Richard Webber, who has him earmarked for chief resident. Skilled, dedicated and a great practitioner of patient focused care, he appears faultless.
But could his attraction to Meredith and his unflinching determination to woo her be his downfall? With fellow senior surgeon Preston Burke hot on his heals, there’s no room for mess ups.

A force to be reckoned with, Cristina has an academically brilliant background and is determined to climb the ladder to success, whatever the cost. She doesn’t care what the other interns think of her she makes sure they know it.

Sandra Oh is aggressive, cut throat and arrogant. Unsurprisingly, she has no bedside manner and no concept of how to relate to her patients. But when a former Grace Hospital nurse ends up being one of her patients we see a glimmer of emotion, suggesting that her tough exterior might have a softer side.